[HTML][HTML] Accurate whole human genome sequencing using reversible terminator chemistry
DNA sequence information underpins genetic research, enabling discoveries of important
biological or medical benefit. Sequencing projects have traditionally used long (400–800 …
biological or medical benefit. Sequencing projects have traditionally used long (400–800 …
High-throughput sequencing of DNA G-quadruplex structures in the human genome
…, G Marsico, JM Boutell, M Di Antonio, GP Smith… - Nature …, 2015 - nature.com
G-quadruplexes (G4s) are nucleic acid secondary structures that form within guanine-rich
DNA or RNA sequences. G4 formation can affect chromatin architecture and gene regulation …
DNA or RNA sequences. G4 formation can affect chromatin architecture and gene regulation …
[HTML][HTML] Rapid whole-genome sequencing for investigation of a neonatal MRSA outbreak
…, JR Betley, OB Schulz-Trieglaff, GP Smith… - … England Journal of …, 2012 - Mass Medical Soc
Background Isolates of methicillin-resistant Staphylococcus aureus (MRSA) belonging to a
single lineage are often indistinguishable by means of current typing techniques. Whole-…
single lineage are often indistinguishable by means of current typing techniques. Whole-…
A culture-independent sequence-based metagenomics approach to the investigation of an outbreak of Shiga-toxigenic Escherichia coli O104: H4
Importance Identification of the bacterium responsible for an outbreak can aid in disease
management. However, traditional culture-based diagnosis can be difficult, particularly if no …
management. However, traditional culture-based diagnosis can be difficult, particularly if no …
Google Internet search activity and volatility prediction in the market for foreign currency
GP Smith - Finance Research Letters, 2012 - Elsevier
I study whether evolution in the number of Google Internet searches for particular keywords
can predict volatility in the market for foreign currency. I find that data on Google searches for …
can predict volatility in the market for foreign currency. I find that data on Google searches for …
Rapid single-colony whole-genome sequencing of bacterial pathogens
…, J Parkhill, NA Gormley, GP Smith… - Journal of …, 2014 - academic.oup.com
Objectives As a result of the introduction of rapid benchtop sequencers, the time required to
subculture a bacterial pathogen to extract sufficient DNA for library preparation can now …
subculture a bacterial pathogen to extract sufficient DNA for library preparation can now …
Rapid whole-genome sequencing for investigation of a suspected tuberculosis outbreak
…, MJ Ellington, SD Bentley, GP Smith… - Journal of clinical …, 2013 - Am Soc Microbiol
Two Southeast Asian students attending the same school in the United Kingdom presented
with pulmonary tuberculosis. An epidemiological investigation failed to link the two cases, …
with pulmonary tuberculosis. An epidemiological investigation failed to link the two cases, …
Protection of erythrocytes from human complement–mediated lysis by membrane-targeted recombinant soluble CD59: a new approach to PNH therapy
…, GP Smith, SJ Richards, J White, RAG Smith, P Hillmen - Blood, 2006 - ashpublications.org
Paroxysmal nocturnal hemoglobinuria (PNH) results from the expansion of a hematopoietic
clone that is deficient in glycosylphosphatidylinositol-anchored molecules. PNH is …
clone that is deficient in glycosylphosphatidylinositol-anchored molecules. PNH is …
Membrane-targeted complement inhibitors
GP Smith, RAG Smith - Molecular immunology, 2001 - Elsevier
Undesirable complement activation contributes to the pathology of many human diseases by
damaging tissue and promoting inflammation. Because complement-mediated damage is …
damaging tissue and promoting inflammation. Because complement-mediated damage is …
Highly sensitive profiling of CD44+/CD24− breast cancer stem cells by combining global mRNA amplification and next generation sequencing: evidence for a …
…, S Luo, Y Wiencek, E Kantelhardt, C Vess, GP Smith… - Cancer letters, 2012 - Elsevier
We performed next generation sequencing- and microarray-based gene expression profiling
of CD44 + /CD24 − /CD45 − breast CSCs (cancer stem cells) isolated from primary ERα-…
of CD44 + /CD24 − /CD45 − breast CSCs (cancer stem cells) isolated from primary ERα-…