Background Less than 30% of the cases of Brugada syndrome (BrS) have an identified
genetic cause. Of the known BrS-susceptibility genes, loss-of-function mutations in SCN5A or …

Increased cardiac contractility during the fight-or-flight response is caused by β-adrenergic
augmentation of Ca V 1.2 voltage-gated calcium channels 1 , 2 , 3 – 4 . However, this …

Importance Critical illness, a marked inflammatory response, and viruses such as SARS-CoV-2
may prolong corrected QT interval (QTc). Objective To evaluate baseline QTc interval on …

The coronavirus disease 2019 (COVID-19) can result in a hyperinflammatory state, leading
to acute respiratory distress syndrome (ARDS), myocardial injury, and thrombotic …

Rationale: Changing activity of cardiac Ca V 1.2 channels under basal conditions, during
sympathetic activation, and in heart failure is a major determinant of cardiac physiology and …

Rationale: Fibroblast growth factor homologous factors (FHFs), a subfamily of fibroblast
growth factors (FGFs) that are incapable of functioning as growth factors, are intracellular …

The identification of a gain-of-function mutation in CACNA1C as the cause of Timothy Syndrome
(TS), a rare disorder characterized by cardiac arrhythmias and syndactyly, highlighted …

Rationale: Fibroblast growth factor (FGF) homologous factors (FHFs; FGF11–14) are
intracellular modulators of voltage-gated Na + channels, but their cellular distribution in …

Mutations in CACNA1C that increase current through the Ca V 1.2 L-type Ca 2+ channel
underlie rare forms of long QT syndrome (LQTS), and Timothy syndrome (TS). We identified a …

There is growing evidence that COVID-19 can cause cardiovascular complications. However,
there are limited data on the characteristics and importance of atrial arrhythmia (AA) in …