The Journal of Investing (JOI) is a scholarly journal for the financial services industry, appealing
to both the academic and practitioner audiences. The JOI offers practical analysis and …

Acid-sensing ion channels (ASICs) are mainly proton-gated cation channels that are activated
by pH drops and nonproton ligands. They are part of the degenerin/epithelial sodium …

The term ‘futility’ is used to refer to the inability of a clinical trial to achieve its objectives. In
particular, stopping a clinical trial when the interim results suggest that it is unlikely to achieve …

Background Respiratory syncytial virus (RSV) infection causes considerable illness in older
adults. The efficacy and safety of an investigational bivalent RSV prefusion F protein–based (…

Objective Aging is a major risk factor for numerous neurological disorders, and the mechanisms
underlying brain aging remain elusive. Recent animal studies demonstrated a tight …

The variability of monthly mean sea-surface temperature (SST) anomalies over the extratropical
North Atlantic and Pacific and its relation to atmospheric circulation anomalies over the …

Deletion of Lsh perturbs DNA methylation patterns in mice yet it is unknown whether Lsh
plays a direct role in the methylation process. Two types of methylation pathways have been …

This analysis represents the longest‐term follow‐up for patients with acute myeloid leukemia
(AML) treated with 400 mg of venetoclax plus azacitidine or decitabine. Adults with newly …

We report here the first three-dimensional structure of the type 1 inositol 1, 4, 5-trisphosphate
receptor (IP 3 R). From cryo-electron microscopic images of purified receptors embedded in …

Effective treatment options are limited for patients with acute myeloid leukemia (AML) who
cannot tolerate intensive chemotherapy. Adults age ≥18 years with newly diagnosed AML …