[HTML][HTML] Collateral damage: the impact on outcomes from cancer surgery of the COVID-19 pandemic

…, S Jhanji, SA Boyce, F Gronthoud, P Ward, JM Handy… - Annals of …, 2020 - Elsevier
Background Cancer diagnostics and surgery have been disrupted by the response of health
care services to the coronavirus disease 2019 (COVID-19) pandemic. Progression of …

[BOOK][B] Oh's Intensive Care Manual E-Book

AD Bersten, J Handy - 2013 - books.google.com
Whether you’re a newcomer to the ICU or a seasoned practitioner, Oh's Intensive Care Manual
delivers the practical, expert answers you need to manage the conditions you see every …

[HTML][HTML] Reactive oxygen species and p38 mitogen-activated protein kinase mediate tumor necrosis factor α-converting enzyme (TACE/ADAM-17) activation in primary …

…, L Williams, JO Dokpesi, L Tatton, JM Handy… - Journal of Biological …, 2011 - ASBMB
Tumor necrosis factor α-converting enzyme (TACE) is responsible for the shedding of cell
surface TNF. Studies suggest that reactive oxygen species (ROS) mediate up-regulation of …

Low baseline bispectral index of the electroencephalogram in patients with dementia

M Renna, J Handy, A Shah - Anesthesia & Analgesia, 2003 - journals.lww.com
The baseline value of the Bispectral Index (BIS) is 96–99 in the awake state. Patients with
Alzheimer’s disease or vascular dementia may show an increase in slow wave and a …

[HTML][HTML] Construct validity of the Chelsea critical care physical assessment tool: an observational study of recovery from critical illness

EJ Corner, N Soni, JM Handy, SJ Brett - Critical Care, 2014 - Springer
Introduction Intensive care unit-acquired weakness (ICU-AW) is common in survivors of
critical illness, resulting in global weakness and functional deficit. Although ICU-AW is well …

[HTML][HTML] Circulating microvesicles are elevated acutely following major burns injury and associated with clinical severity

…, JR Porter, N Tirlapur, U Katbeh, S Singh, JM Handy… - PloS one, 2016 - journals.plos.org
Microvesicles are cell-derived signaling particles emerging as important mediators and
biomarkers of systemic inflammation, but their production in severe burn injury patients has not …

The responsiveness of the Chelsea Critical Care Physical Assessment tool in measuring functional recovery in the burns critical care population: An observational …

…, KM Attrill, MP Vizcaychipi, SJ Brett, JM Handy - Burns, 2015 - Elsevier
Introduction Severe burn leads to a state of hypercatabolism, resulting in rapid muscle loss
and long-term disability. As survival rates from severe burn are improving, early rehabilitation …

Pain Assessment in INT ensive care (PAINT): an observational study of physician‐documented pain assessment in 45 intensive care units in the United Kingdom

…, O Clancy, N Whitehead, G Kooner, J Handy… - …, 2017 - Wiley Online Library
Pain is a common and distressing symptom experienced by intensive care patients.
Assessing pain in this environment is challenging, and published guidelines have been …

Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity

I Barone, NM Gilette, H Hawks-Mayer, J Handy… - Science …, 2023 - science.org
The time of day strongly influences adaptive behaviors like long-term memory, but the correlating
synaptic and molecular mechanisms remain unclear. The circadian clock comprises a …

Mathematical modelling of the acid–base chemistry and oxygenation of blood: a mass balance, mass action approach including plasma and red blood cells

SE Rees, E Klęstrup, J Handy, S Andreassen… - European journal of …, 2010 - Springer
Mathematical models of the acid–base chemistry of blood based upon mass action and
mass balance equations have become popular as diagnostic tools in intensive care. The …