As a remedy for the notorious deficiency of pre-Civil War US macroeconomic data, this study
introduces an annual index of American industrial production consistently defined from …

Cryo-electron microscopy (cryo-EM) single-particle analysis has proven powerful in
determining the structures of rigid macromolecules. However, many imaged protein complexes …

The NBER's pre–World War I dating of business cycles implies that the US economy spent
nearly every other year in recession. This article extends earlier efforts at redating for the 1796…

We present a strategy for tackling preferred specimen orientation in single-particle cryogenic
electron microscopy by employing tilts during data collection. We also describe a tool to …

In a prospective study of the complications of cardiac resuscitation, 705 cases were
autopsied to identify the cause of death and the pathologic findings attributable to cardiac …

Background The engineering of many-component, synthetic biological systems is being made
easier by the development of collections of reusable, standard biological parts. However, …

We have generated a series of variable-strength, constitutive, bacterial promoters that act
predictably in different sequence contexts, span two orders of magnitude in strength and …

The ribosome is a complex macromolecular machine and serves as an ideal system for
understanding biological macromolecular assembly. Direct observation of ribosome assembly in …

Cryo-electron tomography (cryo-ET) enables observation of macromolecular complexes in
their native, spatially contextualized cellular environment. Cryo-ET processing software to …

Single-particle cryogenic electron microscopy (cryo-EM) has emerged as a powerful technique
to visualize the structural landscape sampled by a protein complex. However, algorithmic …