A mysterious feature of Crohn's disease (CD) is the extra-intestinal manifestation of "creeping
fat" (CrF), defined as expansion of mesenteric adipose tissue around the inflamed and …

The burgeoning obesity and diabetes epidemics threaten health worldwide, yet the
molecular mechanisms underlying these phenomena are incompletely understood. Recently, …

Late eating has been linked to obesity risk. It is unclear whether this is caused by changes
in hunger and appetite, energy expenditure, or both, and whether molecular pathways in …

Protein dephosphorylation by phosphatase PP1 plays a central role in mediating the effects
of insulin on glucose and lipid metabolism. A PP1C-targeting protein expressed in 3T3-L1 …

Chinese translation Background: Insufficient sleep increases the risk for insulin resistance,
type 2 diabetes, and obesity, suggesting that sleep restriction may impair peripheral …

BNip3 localizes to the outer mitochondrial membrane, where it functions in mitophagy and
mitochondrial dynamics. While the BNip3 protein is constitutively expressed in adult liver from …

The peroxisome proliferator-activated receptor γ (PPARγ) is a central regulator of adipogenesis
and recruits coactivator proteins in response to ligand. However, the role of another …

During obesity, adipose tissue macrophages (ATMs) adopt a metabolically activated (MMe)
phenotype. However, the functions of MMe macrophages are poorly understood. Here, we …

Insulin stimulates the activity of mitogen-activated protein kinase (MAPK) via its upstream
activator, MAPK kinase (MEK), a dual specificity kinase that phosphorylates MAPK on …

Glycogen is the storage form of carbohydrate for virtually every organism from yeast to
primates. Most mammalian tissues store glucose as glycogen, with the major depots located in …